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ARNIに腎保護?

長澤将
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論文紹介です。

Butt JH, McMurray JJ, Claggett BL, Jhund PS, Neuen BL, Mc Causland F, Desai A, Lam CS, Pitt B, Pfeffer MA, Packer M, Beldhuis I, Voors AA, Zannad F, Heerspink HJ, Solomon SD, Vaduganathan M. Therapeutic Effects of Heart Failure Medical Therapies on Standardized Kidney Outcomes: Comprehensive Individual Participant-Level Analysis of 6 Randomized Clinical Trials. Circulation. 2024 Sep 1. doi: 10.1161/CIRCULATIONAHA.124.071110. Epub ahead of print. PMID: 39217458.


ARNIで腎をエンドポイントした研究がないと下記の本で書きましたがありました。

ヒットを狙え!Dr. 長澤に聞く腎臓病の薬の使い方
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UK HARP-III Collaborative Group. Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III-rationale, trial design and baseline data. Nephrol Dial Transplant. 2017 Dec 1;32(12):2043-2051. doi: 10.1093/ndt/gfw321. PMID: 27646835; PMCID: PMC5837485.


Haynes R, Judge PK, Staplin N, Herrington WG, Storey BC, Bethel A, Bowman L, Brunskill N, Cockwell P, Hill M, Kalra PA, McMurray JJV, Taal M, Wheeler DC, Landray MJ, Baigent C. Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease. Circulation. 2018 Oct 9;138(15):1505-1514. doi: 10.1161/CIRCULATIONAHA.118.034818. PMID: 30002098.

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