腸内細菌叢が肝疾患に及ぼす影響とその将来性-腸管バリアー障害と微生物代謝産物の観点から
腸内細菌叢が肝疾患に及ぼす影響とその将来性-腸管バリアー障害と微生物代謝産物の観点から
Journal of Gastroenterology and Hepatology
Review ArticleFree Access
Effect of intestinal microbiota on liver disease and its related future prospection, from the perspective of intestinal barrier damage and microbial metabolites
Nan Jiang, Yuanyuan Xiao, Kefei Yuan, Zhen Wang
First published: 20 January 2023
https://doi.org/10.1111/jgh.16129
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jgh.16129.
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Abstract
Liver diseases contribute notably to the global concern of mortality and disease. Emerging evidence has demonstrated that intestinal microbiota can regulate intestinal barrier function and produce bioactive metabolites. Failure of any aspect of this barrier can result in the translocation of microbes into the blood and sustained inflammatory response that promotes liver injury, fibrosis, and cirrhosis. Here, we review the mechanisms by that intestinal microbiota regulate the intestinal barrier. The multiple underlying mechanisms of intestinal microbiota in liver disease are elaborated in detail, emphasizing them as the bridge linking the liver with gut microbiota. Thus, we highlight the feasibility of targeting the gut-liver axis for treating liver diseases.
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