スケールを超えて共有される微生物代謝の定量的原理
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公開日:2024年8月6日
スケールを超えて共有される微生物代謝の定量的原理
ネイチャー微生物学 音量 9、 ページ1940–1953 ( 2024 )この記事を引用
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代謝は、あらゆる細胞や生物の中で起こる化学反応の複雑なネットワークであり、生命を維持し、生態系のプロセスを媒介し、地球の気候に影響を与えています。微生物代謝の実験やモデルは、多くの場合、1 つの特定のスケールに焦点を当てており、分子、細胞、生態系間のつながりが見落とされています。ここでは、スケールを超えて共通性を示す定量的な代謝原理に焦点を当て、微生物の生命に関する統合的な視点を実現するのに役立つ可能性があると主張します。質量、電子、エネルギーのバランスは、代謝ネットワーク、生物、生態系内での流れに定量的な制約を提供し、それぞれが環境にどのように反応するかを形作ります。酵素と基質の相互作用など、これらの流れの基礎となるメカニズムには、細胞と資源、または捕食者と被食者の場合と同様の方程式で表される遭遇と処理の段階が含まれることがよくあります。これらの形式的な類似点は共通の原理を反映していると提案し、実験とモデルによる調査が、スケールを超えて微生物代謝を研究するための共通言語にどのように貢献するかについて説明します。
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Acknowledgements
We thank R. Braakman, J. Casey, S. Ben Tabou de Leon and O. Weissberg for critical reading of the manuscript. The joint work of the research groups of D. Sher, D. Segrè and M.J.F. was supported by the Gordon and Betty Moore Foundation (grant number GBMF #3778 to M.J.F.), Human Frontier Science Program (grant number RGP0020/2016 to D. Sher and D. Segrè), United States–Israel Binational Science Foundation (grant number 2010183 to D. Sher and M.J.F.), Israel Science Foundation (grant number 1786/20 to D. Sher) and National Science Foundation/United States–Israel Binational Science Foundation (NSFOCE-BSF 1635070 and NSF-BSF 2246707 to D. Segrè and D. Sher). M.J.F. is also grateful for support from the Simons Foundation (CBIOMES; grant number 549931 to M.J.F.). D. Segrè was also supported by the National Science Foundation Center for Chemical Currencies of a Microbial Planet (C-CoMP publication #047 ), National Institutes of Health (National Institute on Aging (award number UH2AG064704) and National Cancer Institute (grant number R21CA279630)) and US Department of Energy, Office of Science, Office of Biological and Environmental Research through the Microbial Community Analysis and Functional Evaluation in Soils (m-CAFEs) Science Focus Area Program under contract number DE-AC02-05CH11231 to the Lawrence Berkeley National Laboratory.
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Authors and Affiliations
Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Haifa, Israel
Daniel Sher
Department of Biology, Boston University, Boston, MA, USA
Daniel Segrè
Biological Design Center, Boston University, Boston, MA, USA
Daniel Segrè
Bioinformatics Program, Faculty of Computing and Data Sciences, Boston University, Boston, MA, USA
Daniel Segrè
Department of Physics, Boston University, Boston, MA, USA
Daniel Segrè
Department of Biomedical Engineering, Boston University, Boston, MA, USA
Daniel Segrè
Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
Michael J. Follows
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All of the authors contributed equally to all aspects of this article.
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Correspondence to Daniel Sher, Daniel Segrè or Michael J. Follows.
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Sher, D., Segrè, D. & Follows, MJ スケールを超えて共有される微生物代謝の定量的原理。Nat Microbiol 9、1940–1953(2024)。https://doi.org/10.1038/s41564-024-01764-0
受け取った2023年6月24日
承認済み2024年6月18日
公開済み2024年8月6日
発行日2024年8月
掲載日https://doi.org/10.1038/s41564-024-01764-0
科目
自然微生物学 ( Nat Microbiol ) ISSN 2058-5276(オンライン)
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